Specializations
- Organic synthesis
- Mass tags
- Mass spectrometry
- DNA adductomics
Overview
Prior to joining Northeastern University, Roger Giese obtained a PhD in organic chemistry at MIT and then underwent postdoctoral training in biophysics and clinical chemistry at the Brigham and Women’s Hospital, Harvard Medical School, with a research focus on chemical modification of proteins to help elucidate their structures and functions. Dr. Giese’s research at NU initially focused on the avidin-biotin system as a tool in analytical biochemistry. Subsequently he focused on biomedical applications of mass tag mass spectrometry. The major area of application for this technology has been DNA adductomics, with secondary applications in the fields of metabolomics, exposome, and drug analysis. In his earlier years at NU he taught courses in clinical chemistry and biomedical chemical analysis. In recent years he has taught two courses: undergraduate biochemistry to pharmacy students in my Department of Pharmaceutical Sciences, and graduate pharmaceutical biochemistry in the same department. In the latter course the biochemistry of leading and emerging drugs is presented.
Awards
2010 Innovation Teaching Award, Northeastern University
1999 Klein Lecturer, Northeastern University
1965-1966 Woodrow Wilson Fellowship
1961-1965 George McPherson Scholarship
1964 Bluhm Scholarship and Service Award
Grants
Source: NIH
Title: Miniature Devices for Electrophoretic Sample Preparation
Source: NCI
Title: Ultrasensitive Measurement of Estrogens
Source: NIEHS
Title: Puerto Rico Testsite for Exploring Contamination Threats
Source: NIH
Title: Breath Test for Profiling Drugs of Abuse, Partnership for Clean Competition Mitf: A Master Gene for Melanocyte Development
Recent Publications
Cellai, F., Munnia, A., Viti, J., Doumett, S., Ravagli, C., Ceni, E., Mello, T., Polvani, S., Giese, R. W., Baldi, G., Galli, A., Peluso, M.E. M. (2017) Magnetic Hyperthermia and Oxidative Damage to DNA of Human Hepatocarcinoma Cells, Int. J. Mol. 18, 1-15. Doi:10.3390/ijms18050939.
Giese, R.W. (2017) Interview, MetaboNews, February Issue 66.
Munnia A., Giese, R. W., Polvani, S., Galli, A., Cellai, F., Peluso, M.E.M. (2017) Bulky DNA Adducts, Tobacco Smoking, Genetic Susceptibility, and Lung Cancer Risk, in Advances in Clinical Chemistry, Makowski, G.S., ed., Academic Press, 231-277.
Shao, G., Agar, J., Giese, R. W., (2017) Cold-Induced Aqueous Acetonitrile Phase Separation: A SaltFree Way to Begin QuEChERS, J. Chromatogr. A 1506, 128-133. doi.org/10.1016/j.chroma.2017.05.045
Pleil, J. Giese, R.W. (2017) Integrating exhaled breath diagnostics by disease-sniffing dogs with instrumental laboratory analysis, J. Breath Res. 11, 032001. doi.org/10.1088/1752-7163/aa79bc
Cordero, J. F., Meeker, J.D., Loch-Caruso, Giese, R., Padilla, I., Vesper, D., Kaeli, D., Sheahan, T., Brown, P., Velez-Vega C. M., Alshawabkeh, A. N. (2018) Team Science Applied to Environmental Health Research: Karst Hydrogeology and Preterm Birth in Puerto Rico, In: White, W., Herman, J., Herman, E., Rutigliano, M,. (eds) Karst Ground water Contamination and Public Health, Advances in Karst Science Springer, Cham.
Giese, R. W. and Wang. P. (2018) Cationic Tags for Attomole Level Detection of Analytes by Mass Spectrometry, U.S. Patent 10,036,743.
Wang, P. Giese, R. W. (2018) Interpretation of Mass Spectral Data for the Ciplatin 1,2 Intrastrand Guanine-Guanine Adduct, Chem. Res. Toxicol. doi:10.1021/acs.chemrestox.8b00134
Giese, R. G., Shao, G., MacNeil, M., Wang, P. (2018) Caged Bags of Porous Materials, US Patent Application Number 13/955,512, allowed.
