Coinciding with the recent progress in structural understanding of receptor targets, I strive to advance neuropharmacology research that allows rational drug design. Work from my laboratory encompasses molecular pharmacology, neurophysiology, electrophysiology, and biophysics to answer important biological questions by using various in vitro assays and biosensors. My laboratory tries to elucidate mechanisms for neuromodulator receptors (e.g., dopamine, muscarinic, and cannabinoid receptors) that allow discovery of unique ligands employing biased agonism or allosterism and develop novel medications for neuropsychiatric illnesses (e.g., movement disorders, schizophrenia and drug abuse.)
Yano H+, Guerrero AM, Kumar V, Hoffman AF, Lupica CR, Shi L, Newman AH, Novel and potent dopamine D2 receptor Go-protein biased agonists. +equally contributed. ACS Pharm. & Tansl. Sci. 2019 Feb 8; 2(1): 52–65. (cover, editors’ choice)
Yano H*, Cai NS, Javitch JA, Ferré S, Luciferase complementation based-detection of G protein coupled receptor activity, *corresponding, Biotechniques. 2018 Jul;65(1):9-14.
Yano H*, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S, Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor. *corresponding. Nat Commun. 2018 Feb 5;9(1):486. (featured on NIDA website)
Yano H*, Bonifazi A, Xu M, Guthrie D, Schneck, SN, Abramyan A, Fant A, Hong WC, Newman AH, Shi L*, Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomerization assays. *co-corresponding, Neuropharmacology. 2018 Jan 31;133:264-275.
Yano H*, Provasi D, Cai NS, Filizola M, Ferré S, Javitch JA*, Development of novel biosensors to study receptormediated activation of the G-protein α subunits Gs and Golf. *corresponding. J Biol Chem. 2017 VOL. 292, NO. 49, pp. 19989–19998
Bonifazi A+, Yano H+, Ellenberger MP, Muller L, Kumar V, Zou MF, Cai NS, Guerrero AM, Woods AS, Shi L, Newman AH, Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism. +equally contributed. J Med Chem. 2017, Mar 16.
Frederick AL+, Yano H+, Trifilieff P+, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD+, Javitch JA+, Evidence against dopamine D1/D2 receptor heteromers. +equally contributed. Mol Psychiatry. 2015 VOL. 20, NO. 11, pp. 1373-85.
Urizar E+, Yano H+, Kolster R, Galés C, Lambert N, Javitch JA, Functional Selectivity at the GPCR heteromer level: Receptor partner selection affects pharmacology. +equally contributed. Nat Chem Biol. 2011 VOL. 7, NO. 9, pp. 624-630.