Richard I. Duclos Jr.

Research Assistant Professor
  • Department of Pharmaceutical Sciences

Office: 140 TF Room123
Phone: 617-373-3163

B.S., Chemistry, University of New Hampshire
Ph.D., Chemistry, University of California, Berkeley

Synthetic Chemistry
Protein Biochemistry

Major Research Areas:
Lipid syntheses, including chemoenzymatic and radiosyntheses
Lipid transport, organization, and metabolism
Biochemical assay development

Selected Publications:
R. I. Duclos, Jr. and A. Makriyannis, "Syntheses of All Four Stereoisomers Which Are Conformationally Constrained 1,4-Dioxanyl Analogs of the Antineoplastic Ether Lipid ET-18-OCH3," J. Org. Chem. 1992, 57, 6156-6163. 

R. I. Duclos, Jr., "Synthesis of 1-palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine(PHPC)," Chem. Phys. Lipids 1993, 66, 161-170. 

K. Saxena, R. I. Duclos, P. Zimmermann, R. R. Schmidt and G. G. Shipley, "Structure and properties of totally synthetic galacto- and gluco-cerebrosides," J. Lipid Res. 1999, 40, 839-849. 

R. I. Duclos, Jr., "The total synthesis of ganglioside GM3," Carb. Res. 2000, 328, 489-507. 

R. I. Duclos, Jr., "The total syntheses of Derythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine intermediate," Chem. Phys. Lipids 2001,111, 111-138. 

H.  Zheng, R. I. Duclos, Jr., C. C. Smith, H. W. Farber, R. A. Zoeller, "Synthesis and biological properties of the fluorescent ether lipid precursor, 1-O-[9'-(1"-pyrenyl)]nonyl-sn-glycerol,"J. Lipid Res. 2006, 47, 633-642.

R. I. Duclos, Jr., S. J. Gatley, S. R. Bhatt, M. Johnston, "The preparation of 2-O-[1'14C]arachidonoyl-1-O-stearoyl-sn-glycerol," J. Labelled Comp. Radiopharm. 2009, 52, 324-326.

R. I. Duclos, Jr., "The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-13C3 and –2,1'-13C2 by a novel multienzyme method," Chem. Phys. Lipids 2010, 163, 102-109.

J. Guo, R. I. Duclos, Jr., V. Kiran Vemuri, A. Makriyannis, "The conformations of 17b-estradiol (E2) and 17a-estradiol as determined by solution NMR," Tetrahedron Lett. 2010, 51, 3465-3469.

R. I. Duclos, Jr., M. Johnston,S. K. Vadivel,A. Makriyannis, S. T. Glaser,S. J. Gatley, "A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG)," J. Org. Chem. 2011, 76, 2049-2055.

M. Johnston, S.R. Bhatt, S. Sikka, R.W. Mercier, J.M. West, A. Makriyannis, S.J. Gatley, R.I. Duclos, Jr. "Assay and Inhibition of Diacylglycerol Lipase Activity," Bioorg.Med.Chem.Lett. 2012, 22, 4585-4592.

R. I. Duclos, Jr., X. Li, M. Carraway, H. Herscovitz, A. Gulati, W. Qiu and G. G. Shipley, “Expression and purification of the extracellular domains of the human low density lipoprotein receptor,” (Manuscript in Preparation).