Jason Guo

Research Assistant Professor and Assistant Director of the NMR Facility
  • Center for Drug Discovery
  • School of Pharmacy

Office: 8 Hurtig Hall
Phone: 617-373-4219
Email: j.guo@neu.edu

B.S. Physics, East China Normal University
Ph.D. Pharmaceutical Science, University of Connecticut

Nuclear Magnetic Resonance (NMR) spectroscopy
Ligand-protein interactions
Membrane protein biophysics
Molecular simulations

Fatty acid binding proteins (FABPs) as potental drug targets
Structural determinants of cannabinoid receptors interacting wtih G-proteins
Mechanism of drug transport across cell membranes

Selected Publications:     

  1. Jianqin Zhuang, De-Ping Yang, Spyros P. Nikas, Jianhong Zhao, Jianxin Guo*, and Alexandros Makriyannis*, The interaction of Fatty Acid Amide Hydrolase (FAAH) inhibitors with an anandamide carrier protein using 19F-NMR, The AAPS J. 15: 477-482, 2013. *Co-corresponding authors.
  2. Jianxin Guo, Richard I. Duclos Jr., V. Kiran Vemuri and Alexandros Makriyannis, The conformations of 17β-estradiol (E2) and 17α-estradiol as determined by solution NMR, Tetrahedron Lett. 51: 3465-3469, 2010.
  3. Jianxin Guo, De-Ping Yang, Ravi Chari, Xiaoyu Tian, Spiro Pavlopoulos, Dai Lu and Alexandros Makriyannis, Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers, J. Med. Chem. 51:6793-6799, 2008.
  4. Xiaoyu Tian, Jianxin Guo, Fenmei Yao, De-ping Yang and Alexandros Makriyannis, The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer, J. Biol. Chem. 280: 29788-29795, 2005.
  5. Jianxin Guo, Spiro Pavlopoulos, Xiaoyu Tian, Dai Lu, De-Ping Yang and Alexandros Makriyannis, Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR, J. Med. Chem. 46:4838-4846, 2003.
  6. Jianxin Guo and Xi-An Mao, Longitudinal relaxation effects on transverse magnetization and the nuclear magnetic resonance line shape, Phys. Rev. B 50:13461-13466, 1994.