Richard I. Duclos Jr.Research Assistant Professor
- Department of Pharmaceutical Sciences
Office: 140 TF Room123
B.S., Chemistry, University of New Hampshire
Ph.D., Chemistry, University of California, Berkeley
Major Research Areas:
Lipid syntheses, including chemoenzymatic and radiosyntheses
Lipid transport, organization, and metabolism
Biochemical assay development
R. I. Duclos, Jr. and A. Makriyannis, “Syntheses of All Four Stereoisomers Which Are Conformationally Constrained 1,4-Dioxanyl Analogs of the Antineoplastic Ether Lipid ET-18-OCH3,” J. Org. Chem. 1992, 57, 6156-6163.
R. I. Duclos, Jr., “Synthesis of 1-palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine(PHPC),” Chem. Phys. Lipids 1993, 66, 161-170.
K. Saxena, R. I. Duclos, P. Zimmermann, R. R. Schmidt and G. G. Shipley, “Structure and properties of totally synthetic galacto- and gluco-cerebrosides,” J. Lipid Res. 1999, 40, 839-849.
R. I. Duclos, Jr., “The total synthesis of ganglioside GM3,” Carb. Res. 2000, 328, 489-507.
R. I. Duclos, Jr., “The total syntheses of D–erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine intermediate,” Chem. Phys. Lipids 2001,111, 111-138.
H. Zheng, R. I. Duclos, Jr., C. C. Smith, H. W. Farber, R. A. Zoeller, “Synthesis and biological properties of the fluorescent ether lipid precursor, 1-O-[9′-(1″-pyrenyl)]nonyl-sn-glycerol,”J. Lipid Res. 2006, 47, 633-642.
R. I. Duclos, Jr., S. J. Gatley, S. R. Bhatt, M. Johnston, “The preparation of 2-O-[1′14C]arachidonoyl-1-O-stearoyl-sn-glycerol,” J. Labelled Comp. Radiopharm. 2009, 52, 324-326.
R. I. Duclos, Jr., “The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1′-13C3 and –2,1′-13C2 by a novel multienzyme method,” Chem. Phys. Lipids 2010, 163, 102-109.
J. Guo, R. I. Duclos, Jr., V. Kiran Vemuri, A. Makriyannis, “The conformations of 17b-estradiol (E2) and 17a-estradiol as determined by solution NMR,” Tetrahedron Lett. 2010, 51, 3465-3469.
R. I. Duclos, Jr., M. Johnston,S. K. Vadivel,A. Makriyannis, S. T. Glaser,S. J. Gatley, “A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG),” J. Org. Chem. 2011, 76, 2049-2055.
M. Johnston, S.R. Bhatt, S. Sikka, R.W. Mercier, J.M. West, A. Makriyannis, S.J. Gatley, R.I. Duclos, Jr. “Assay and Inhibition of Diacylglycerol Lipase Activity,” Bioorg.Med.Chem.Lett. 2012, 22, 4585-4592.
R. I. Duclos, Jr., X. Li, M. Carraway, H. Herscovitz, A. Gulati, W. Qiu and G. G. Shipley, “Expression and purification of the extracellular domains of the human low density lipoprotein receptor,” (Manuscript in Preparation).